Binding of the Origin Recognition Complex (ORC) to origins of replication marks the first step in the initiation of replication of the genome in all eukaryotic cells.Here, we report the structure of the active form of human ORC determined by X-ray crystallography and cryo-electron microscopy.The complex is composed of an ORC1/4/5 motor module lobe
Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer
Abstract Background The disruption of normal gene Laundry Wash Bag regulation due to microRNA dysfunction is a common event in cancer pathogenesis.MicroRNA-27b is an example of an oncogenic miRNA, and it is frequently upregulated in breast cancer.MicroRNAs have been found to deregulate tumor metabolism, which typically manifests as heightened cellu
Characterization of the complete chloroplast genome of a subalpine deciduous shrub Lonicera angustifolia var. myrtillus (Caprifoliaceae)
The genus Lonicera (Caprifoliaceae) is of great economical significance.It has been taxonomically studied frequently in history, while phylogenetic relationships intra the genus are still obscure.Here, we reported the first species complete chloroplast genome sequence in the section Isoxylosteum, Lonicera angustifolia var.myrtillus.It is 156,222 bp
Specific Combination of Salvianolic Acids As Core Active Ingredients of Danhong Injection for Treatment of Arterial Thrombosis and Its Derived Dry Gangrene
Although single-targeting anti-platelet agents are used extensively in clinics, their limitations in resistance and bleeding have started a trend of combination therapy.Danhong injection (DHI) is a widely prescribed injection medicine for cardiovascular and cerebrovascular diseases in China.However, its precise clinical efficacy and functional comp